Effect of magnesium on restenosis after percutaneous transluminalcoronary angioplasty: a clinical and angiographic evaluation in a randomized patient population

Restenosis is a major clinical problem following successful percutaneous translwninal coronary angioplasty. Since magnesium has vasodilator and antithrombotic effects, this study lvas designed to evaluate its potential to decrease the rate of restenosis. In an open-labelled, randomized controlled study, 148 patients underwent successful coronary angioplasty. Ninetyeightpatients were treated with 46-52 mmoll18-20 h intravenousmagnesiumsulphate (groups lvn and lvf2), and 49 of them continued with oral supplements of magnesium hydroxide 600 mg. day 1 (group 1\.12)-The other 50 patients served as controls (group C). Coronary angiography \Vas peifonned before, immediately after and at 6 months follow-up or earlier if clinically indicated Clinical, laboratory, ergometric and radionuclide evaluations \vere also carried out.